ProArgi9 Plus

June 1, 2009

in Synergy V3

Post image for ProArgi9 Plus

ProArgi-9 Plus is Synergy’s top selling product and the cornerstone of any nutritional regimen. One serving contains 5,000 mg (5 grams) of elemental pharmaceutical grade l-arginine. Often referred to as the ‘miracle molecule’, l-arginine has potent health-enhancing properties. High Desert Heart Institute found very compelling positive results including the potential to reverse heart disease!  See the full results here. There are also many medical publications that have documented the benefits of l-arginine use.  Click here to read more.

L-arginine benefits the body in a myriad of ways. It stimulates the production of nitric oxide in the body….to promote anti-aging properties, sports performance, enhance sexual performance, and boost the immune system. We can’t ignore the power of arginine any longer!
– Dr. Joe Predergast

ProArgi-9 Plus was formulated in collaboration with leading l-arginine researchers such as Dr. Joe Joseph Prendergast and other cardiovascular specialists who have conducted pioneering research in the proper application of l-arginine in promoting cardiovascular health. These experts have helped create the best l-arginine product on the market.

L-arginine is best known for its cardiovascular benefits. In the body, l-arginine is converted to nitric oxide, which relaxes the blood vessels. This reduces stress on the heart and improves circulation. L-arginine is the body’s major source for nitric oxide synthesis. Without nitric oxide, human life would not be possible. L-arginine also reduces blood viscosity. Scientific studies have shown that l-arginine significantly reduces blood pressure levels.

L-arginine also enhances health in a number of other ways. It improves immune function, stimulates the release of human growth hormone (HGH), may boost energy levels, helps to build muscle, and reduces adipose tissue body fat.

ProArgi-9 Plus is a unique product with far-reaching health benefits and powerful support for the cardiovascular system. With ProArgi-9 Plus, you’re giving your body the support necessary for a long, healthy life.

ProArgi-9 Plus now comes in 3 flavors: Citrus Berry, Mixed Berry and Grape.  All have the same powerful active ingredients but have different forms of sweetening, like monk fruit or Xylitol (label information below).


  • Supports cardiovascular health
  • Enhances blood flow to vital organs
  • Combats the negative effects of premature cardiovascular aging
  • Sweetened with Xylitol to enhance oral health
  • May aid in decreasing body fat
  • Anti-aging benefits
  • Stimulates the natural production of HGH (human growth hormone)
  • Maintains healthy blood sugar levels already in normal range
  • May boost energy levels

These and other powerful benefits were documented in a recently completed at the High Desert Heart Institute.  Among them is evidence that shows the potential for a reversal of heart disease!

Listen to the recorded conference call sharing the studies’ preliminary results publicly for the first time.

Audio clip: Adobe Flash Player (version 9 or above) is required to play this audio clip. Download the latest version here. You also need to have JavaScript enabled in your browser.

Read the study summary
Read the full study results here…
ProArgi-9 Plus Live Blood Analysis
Read more clinical documentation and publications here…


Joe Joseph Prendergast, MD, is a distinguished certified physician whose advanced research and experience has contributed significantly to Synergy as well as to the medical and scientific fields as a whole. In addition to his role as a practicing physician for over 35 years, Dr. Joe is an accomplished scientist, researcher, and humanist. His research regarding l-arginine contributed to the development of Synergy’s signature product, ProArgi-9 Plus.

Since 1991, Dr. Joe has been personally using l-arginine and recommending it to his patients. He has become an expert on the many properties and benefits of this amino acid and he understands l-arginine’s essential role in maintaining vital heart health. “L-arginine benefits the body in a myriad of ways,” explains Dr. Joe. “It stimulates the production of nitric oxide in the body, which dilates the blood vessels and helps them relax and restore elasticity. L-arginine is also important in cell division, immunity, and the secretion of hormones. We have now learned more about how l-arginine uses the two natural pathways into the brain to promote anti-aging properties, sports performance, enhance sexual performance, and boost the immune system. We can’t ignore the power of arginine any longer!”

Dr. Joseph Prendergast
• 2008 – ADA “Father of the Year”
• 2005 – AMA Certificate of Recognition
• <1% admissions in 17 years!
• Prestigious Panel Member
• Staff Physician – Stanford

In part due to his use of l-arginine in his clinic, Dr. Joe has a remarkable record of less than 1% patient hospital admissions in 17 years including heart attack or stroke. He has received many awards including “Father of the Year” in 2008 from the American Diabetes Association and the Father’s Day Council of Silicon Valley and a Certificate of Recognition in 2005 from the American Medical Association for demonstrating outstanding commitment to eliminating health care disparities in the area of access.

Dr. Joe is board-certified in internal medicine as well as endocrinology and metabolism. He graduated from Wayne State University in Detroit, Michigan, completed a fellowship in endocrinology and metabolism at Henry Ford Hospital in Detroit, and fulfilled his research fellowship at the University of California, San Francisco. He has served on many prestigious local and national committees and review panels including the American Board of Internal Medicine, the State of California Legislative Task Force on Diabetes and Obesity, and the American Association of Clinical Endocrinologists. Among his many positions, Dr. Joe has served as an Associate Clinical Professor of the Department of Medicine at the University of California Medical Center and is currently a staff physician at Stanford.

Dr. Joe has published 50 medical articles in well-known publications such as the Journal of the American Medical Association and the New England Journal of Medicine and Diabetes Care. In 1986, Dr. Joe formed a single specialty endocrinology practice, Endocrine Metabolic Medical Center, and a non-profit research foundation, Pacific Medical Research Foundation. In 1999, he founded DiabetesWell, an eClinic that helps patients with diabetes lead healthier, longer lives.

From his office in Palo Alto, CA, Dr. Joe sees a variety of patients facing both shortened lifespan and restricted lifestyles. He is one of the foremost practitioners and proponents of l-arginine as a treatment of choice, and through his practice he helps his patients to modify their lifestyles and begin a new, more rewarding life with fewer restrictions and broader opportunities for improvement.



Mix 1 serving (1 scoop providing 5 g elemental L-arginine) with 4-8 oz. water (depending on individual taste).  Stir to dissolve.  If water is very cold, mixture will take about 1 minute to dissolve. One serving (1 scoop) may be taken twice per day.


There are two recommended regimens with differing focuses.  Both have positive effects on the overall body and heart health yet a slightly different in specific benefits.  Click here for more…


L-arginine is a vital amino acid that plays a role in a number of physiological functions in the body, but is best known for its cardiovascular benefits. In the body, l-arginine is converted to nitric oxide, which relaxes the blood vessels and regulates blood vessel tone and flexibility. This reduces stress on the heart, improves circulation, and lowers blood pressure.

The amino acid citrulline is metabolized to yield more l-arginine, which in turn provides additional nitric oxide. Citrulline helps to optimize blood flow throughout the body and promote healthy energy levels.

Folic Acid, Vitamins B6 and B12
These ingredients work together to naturally decrease homocysteine levels.

Red wine extract (Resveratrol)
This ingredient is high in antioxidants, anthocyanins, and polyphenols, which help protect the heart and reduce LDL oxidation.

Pomegranate contains superior antioxidants, known as punicalagins and ellagic acid. Pomegranate may inhibit LDL oxidation, support arterial wall strength, and enhance the activity of eNOS, the enzyme responsible for converting l-arginine to nitric oxide.

Vitamin K2
This vitamin keeps calcium in the bones and out of the arteries.

Vitamin D3
This vitamin has long been known to aid in calcium absorption, but new research shows that D3 also plays a role in healthy cardiovascular function and supports healthy inflammatory response.

Ribose Ribose is a naturally occurring sugar that has been extensively studied for its ability to enhance the recovery of energy compounds in heart cells.

This ingredient is a low glycemic sweetener that occurs naturally in the body. Unlike other sweeteners, xylitol has been shown to provide protection against tooth decay.
Supplemental Facts

L-Arginine Products Side-by-Side Comparison

There are a lot of supplements on the market. Not all are effective and some may even harm you. We’ve put together a comparison of 3 popular l-arginine products. Click here to see how they stack up…


Citrus Berry Mixed Berry Grape Active


{ 6 comments… read them below or add one }

Anantha Krishnamurthi July 20, 2015 at 2:51 am

Dear Sir,
My wife is now 53 yrs old and is a chronic MS (Multiple Sclirosis) patient. Since I came to know of ProArgi9+ I am very curious to use this supplement on my wife to boost up the blood flow in her Central Nrvous System so that the scars and damaged mylien sheaths can be repaird. Will this be possible for MS patients ? Do you have any testimonials to share ?

I am based out of Bangalore, India. These supplements are not available in India. Hence let me know the closest distributor for purchasing ProArgi9+.

Best Regards,
Anantha Krishnamurthi, Bangalore, India


HTM Admin September 15, 2015 at 10:45 am

Thanks for your question. Unfortunately there are restrictions based on individual country import laws. We are not yet distributing in India.


Stephen November 3, 2013 at 11:56 pm

We don’t get ProArgi-9 plus in India and doctors do not prescribe it either. I am taking medication for suspected CAD for a couple of weeks now and the medical practitioners here are not very forthcoming about throwing more light of using l-arginine along with other medications. Would someone be able to help me with this. I could give more details of medication am using if required. Thanks in advance.



HTM Admin November 5, 2013 at 8:32 am

Hello Stephenos,

I’m glad you are looking into ProArgi-9+ for your CAD. It can definitely help.

First off, I’m not aware of the product being available directly in any part of India yet. I’m not sure how you are planning on ordering the product but if you email me directly at we can talk about that more.

Second, as I am not a doctor I cannot speak about prescriptions. I will say this though. I am not aware of any contraindications with ProArgi-9+ at this time. It is a natural compound that supports the bodies ability to naturally heal itself. It is not like medications in this way. It is more like taking a vitamin in comparison.

What I have seen though is when you start taking the product and have improvements in your condition, your need for the drugs will be reduced. Working with your doctor to track this improvement so modifications to your medication levels can be done is important. When all goes well you will be off your medications be your condition has improved so much that you no longer need them.

I wish you well and look forward to hearing from you directly.


Stacey Jackson April 19, 2010 at 5:18 pm

I’m wondering about discontinuing my cholesterol medication and using proargi-9 plus in the one serving packet form. I don’t see this form of proargi on your website? I need to been convinced and reassured at the same time. I don’t like drugs that cause reactions and complications. I have Osteoperosis also with mildly low vitamin D rate.


admin April 22, 2010 at 2:22 pm

Stacey – Thanks for your great question. We cannot give you advice to discontinue use of medication prescribed by a doctor. We do however encourage you to make the decision with your doctor and for yourself based on information you can find here. The clinical trial results of the ProArgi9 Plus are clear in providing a direct benefit (see study info here). It is PROVEN to improve the cholesterol profile (40% decrease in triglycerides – 18% increase in HDL). It was also PROVEN to increase Vitamin D levels by 183% !!

With these results, you can feel confident you will have very positive benefits from using the product.

I can also tell you that doctors with a wholistic approach will tell you it is not the cholesterol number that is the main factor but rather the “stickyness” of that cholesterol that is the issue. Common prescriptions work to reduce the cholesterol amount and not it’s sticky factors. This can help but is not the root cause. ProArgi9 Plus is formulated to address the root causes of heart disease in their fundamental form. It sustains the body to be healthy naturally.

As for the single serving packaging, I’d be happy to make that item available to you. Please just me know and I’ll add it to the cart.


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