ProArgi-9+ – FAQ and information

I’ve received emails from visitors and existing users of ProArgi-9+ alike with questions about the product.  Below are list of questions I’ve forwarded to the Synergy Research Scientists (Curtis Walkcer, M.S, et al) and the response. If you have any question that is not answered below, please feel free to send us an email via our contact page and we’ll get back to you.

Q. Are there any side effects in taking ProArgi-9+ (L-Arginine)? I’ve read about this article – How L-Arginine Works and would like to find out if the same side effects occur from taking ProArgi-9+.
A. L-arginine (the main ingredient in ProArgi-9+) is generally free of side effects when taken orally and appropriately. However, gastrointestinal upset could occur when it is taken in large amounts. The amount of L-arginine in a serving of ProArgi-9+ (5 grams) is not expected to be associated with adverse effects in healthy individuals. According to the 2007 PDR: “Oral supplementation with L-arginine at doses up to 15 grams daily are generally well tolerated. The most common adverse reactions of higher doses – from 15 to 30 grams daily – are nausea, abdominal cramps and diarrhea.”
Other Studies/Articles regarding Oral supplimentation with L-Arginine

Q. What about concerns that consumption of arginine produces very unstable free radicals, nitrogen reactive intermediates etc. Are the anti oxidants in your product sufficient to combat these?
A. Nitric oxide is a potent free radical. The studies linking nitric oxide to development or progression of chronic disease are not associated with supplementation of L-arginine to our knowledge. We feel that the benefits of nitric oxide far outweigh the risks, especially considering the potent antioxidants that we add to the ProArgi-9 Plus formulation.

Q. Regarding the claim that l-arginine is the most bio-available form. I thought that arginine ethyl esther was the most bio-available form.
A. I have not seen a claim that we have made that touts our L-arginine ingredient as the most bioavailable, although it is very bioavailable. Arginine EE is a novel new form L-arginine that we are aware of and have been reviewing. At the present time, we have not seen enough evidence that arginine EE is better than free form L-arginine to warrant a material change.

Q. My daughter has Crohn’s disease, ulcerative colitis,and rheumatoid arthritis. These are all auto-immune diseases. She also has asthma and migraines. Since it is not helpful to boost your immune system in this case, how would ProArgi9 affect her problems?
A. Herbs and nutritional supplement products may be used in two different ways to help support optimal immune system function. Herbs with a tonic action gradually strengthen the immune system over time, while strong immune system stimulants have a more immediate action and should not be used for prolonged periods of time. Immune stimulant herbs should be avoided by persons with autoimmune conditions. However, this does not mean that these individuals should avoid all products that affect the immune system. There is often a fine line between what defines an immune stimulant and an immune modulator/supporter. The ingredients in ProArgi-9 Plus are considered to have tonic, immune supporting properties and are not expected to negatively affect autoimmune disorders. However, we do recommend discussing ProArgi-9 Plus use with a healthcare provider when a preexisting condition is present.

Q. Are the components of your product ProArgi-9+9 ORGANIC?
A. We do have organic certification for the ProArgi-9+ as a finished product.
Our own extensive farm auditing and raw material testing processes ensures that our herbs meet organic standards. Because of our own strict internal testing, we do not pursue third party organic certification for any of our products.
Synergy WorldWide is committed to having the best supplements. When applicable, we purchase organic-certified ingredients. Plants that are wild-crafted are not grown on farms, and hence cannot be certified organic. Plants grown in foreign countries may not candidates for organic certification because those countries do not have organic certification programs. The organic certification process is primarily for marketing purposes. The term organic refers to a growing method of plants that does not utilize any synthetic chemicals. Our own extensive farm auditing and raw material testing processes ensures that our herbs meet organic standards.
Most of our supplements are manufactured in our manufacturing facility in Utah. For individual ingredients that go into our products, Synergy WorldWide sources ingredients from suppliers all around the world. Since ingredient sources can change from time to time, we are unable to specify their country of origin. Regardless of the country of origin, all incoming raw materials are subject to over 300 quality inspections from the time they are put into quarantine upon arrival, up until the finished product is made to ensure they are free of contaminants. This process ensures that only safe and high-quality products are released.
We also inspect our suppliers’ facilities to be sure they are meeting our standards. We only partner with suppliers that meet our strict quality standards. Ingredients from any area in the world (including the U.S.) have potential for contamination with fertilizers, pesticides, heavy metals, or any other type of contamination. For example, a material from China is subject to the same testing as a material from the US. If it does not meet standards, it is simply rejected, no matter the country of origin. Likewise, materials from the US cannot be deemed safe or free of adulterated materials just because they are not from certain countries.
Quality is a factor that sets Synergy apart from the competition. Our supplements are manufactured in our state-of-the-art manufacturing facility under the strict current Good Manufacturing Practices. We have multiple in-house quality control labs to ensure our raw materials and finished products are of the highest quality. Nature’s Sunshine Products manufactures Synergy dietary supplements, and NSP scientists work with Synergy to oversee the design, manufacturing and production of all Synergy products.
NSP is NSF International certified. This is a Registration by NSF International that NSP is in compliance with Good Manufacturing Practices (GMP) as set forth in NSF/ANSI Standard 173-2008, Dietary Supplements, Section 8. These requirements are consistent with the published GMP regulation for dietary supplements as defined in 21 CFR § 111, which was published by the FDA in May 2007. In addition to being NSF certified, our facility is inspected by USDA, FDA, and Australia’s TGA. Our manufacturing facility is TGA certified, which means we meet the Australian Therapeutic Goods Administration Pharmaceutical Standard requirements—the highest standards in our industry.
This link from the Synergy WorldWide website gives information on quality assurance.

Q. Are the product Core Greens made from certified organic vegetables?
A. Core Greens contains natural, whole food ingredients; however, it has not been certified organic.
Most of our herbs are wild-crafted, which means our herbs are hand-harvested from the wild. Wild-crafted herbs are not grown with fertilizers, pesticides, etc. The small percentage of our herbs and ingredients that are grown on farms are always grown using organic growing methods (we inspect each supplier’s farm before we buy from them). Whenever possible, we buy from organic-certified farms.
We buy our herbs from all corners of the globe. Most of the traditionally used herbs are only grown, or grow best, in their native environments. Because we buy our herbs from all corners of the globe, we cannot possibly certify all of the herbs are grown on organic farms. Very few countries outside the U.S. have any kind of standard for organic certification. Because of this, we stand by our Quality Assurance motto: “The Proof is in the Testing.” If any trace of foreign material, including fertilizers, pesticides, or any other matter is found, we reject the batch and refuse to purchase from that vendor again in the future. Therefore when you purchase our products you can be guaranteed the product contains no residues from fertilizers or pesticides or other types of contamination.

Additional Information

L-arginine Research and publications

How does ProArgi-9 work?

{ 81 comments… read them below or add one }

Joe April 13, 2017 at 2:24 am

Is proarginin9 safe to take with 1 kidney?


HTM Admin April 13, 2017 at 7:20 am

There is nothing specific in the product that a single kidney configuration would be sensitive to. As always please check with your doctor. But you are probably fine.


Hussain December 5, 2016 at 7:36 pm

I am taking Pro Argine for just week But I am getting slight chest pain and no other symptoms. is it normal ? kindly advise .


HTM Admin April 13, 2017 at 7:12 am

It would be very odd that you have chest pain related to taking Proargi-9+.


Jun Marquez August 11, 2014 at 4:24 am

Precious Day!

My 76 y/o mother’s result on her 2ECHO was
Normal Left Ventricular dimension with good resting function, calculated ejection fraction of 85%
Mitral inflow pattern consistent with age and /or Grade 1 Left Ventricular diastolic dysfunction
Normal Right Ventricular size and function
Mitral sclerosis with mild regurgitation
Severe degenerative aortic stenosis with mild regurgitation
Atherosclerotic Aorta
Mild pulmonary hypertension

Her symptoms includes, some period of shortness of breath, easy fatigability. I wonder and would like to ask your advice if Proargine9 plus could help with my mother’s case.

Thank you so much! Would love to hear from you the soonest possible

Jun Marquez


HTM Admin August 25, 2014 at 2:40 pm


I’m sorry to hear about your mother. I have a daughter with a heart condition so I am familiar with many of the symptoms you described. However not all are directly related to CVD. Many are though and your mother could very well see noticeable improvements. I would recommend you get her a Jumbo of a flavor she would like. There are 3 to choose from (Citrus Berry, Mixed Berry, Grape). I like the mixed berry. After a day or 2 of testing her tolerability I would ramp up to the dosage used in the study at the High Desert Heart Institute: 4 scoops (4g) a day.

The stenosis and sclerosis will likely be the best to respond. As they improve the other measures will likely as well.

Please keep us posted and we all wish your mother well!


Veksi July 31, 2014 at 11:37 am

My friend gave me 5 doses of Synergy e9. I took it one dose / day. He did not warn me any side effects. Because I have Colitis Ulcerosa / Chrons disease the Synergy e9 caused that I my disease started to react after some years. So I will warn everybody about this substant. It can be good, if you do not have any problems with your stomach. But if you have, please do not use that substant. You really can get ill.
Have a nice day,


HTM Admin August 8, 2014 at 7:34 am


Thanks for sharing your experience. It’s a good reminder that WE must be the ultimate gatekeepers to our bodies. Not all substances are right for everyone. E9 can be a great pick-me-up for many.


Adrian Moh May 11, 2014 at 11:19 pm

Hi there…I have been taking proargi9 2 in the morning and 2 in the evEning for abt 8 weeks now…I just wonder why my blood pressure still remain 130-140/90-80 range..does it suppose to lower the BP ? My ldL also remain high ..overall no improvement of my general health condition..pls advise should I continue !?

Have a blessed day

Adrian Moh


HTM Admin May 20, 2014 at 11:30 am


Not all people respond in the same time frames. You systolic pressures are only barely in the hypertensive ranges. It may take longer for you to see the benefits. That is why we offer a 120-day guarantee. I also noticed you are not an HTM customer. I would love to earn your business. Please send us a quick note find out how.


Carol April 9, 2014 at 12:01 pm

I am on a coumadin regimen for past DVTs. Will this product (ProArgi-9+) affect my PT/INR levels?


HTM Admin April 9, 2014 at 3:50 pm


Make sure you consult your doctor before using any L-Arginine product in combination with other drugs or prescriptions. I recommend that you ask you doctor to look up ProArgi-9+ in his Physician Desk Reference Guide. Proargi-9+ is now featured in this medical standard.

Proargi-9 has bee shown to relax vessel walls and could reduce blood pressure and effect other elements of circulation.


Deborah Poole March 8, 2014 at 9:58 pm

I recently completed chemotherapy for breast cancer. My oncologist had me discontinue taking ProArgi9 while going through chemo. Is there any research which confirms there is no interaction with ProArgi9 and chemo? Now that I am finished which chemo, she wants me to take Arimidex. This will likely mean I will have to discontinue ProArgi9 again, which I do not want to do. Just in the 3 months I have been taking it since completing chemo, my chemo-induced neuropathy has disappeared, and my recovery from the general destruction of chemo has been quite remarkable. Is there any information on Arimidex and interaction with ProArgi9? I would like to have something to show her to convince her to let me continue ProArgi9 should I decide to take the Arimidex. Also, if there is no reason to stop it during chemo, I think that fact should be well-publicized.


HTM Admin March 17, 2014 at 6:45 pm


First of all I want to wish you well in your fight for recovery. It is my experience that treatment advisers will recommend you to discontinue most everything while they administer their programs. This merely protocol to eliminate things they cannot predict.

I am not a doctor but I am not aware of an interaction of l-arginine and chemo. i personally am not a fan of chemo as I feel it to be a draconian approach that often does more harm than good. But again, I’m not a doctor.

What I can tell you is that ProArgi-9+ supports the bodies natural immunities. Chemo tends to destroy them.


Josef October 12, 2013 at 6:03 am

I suffer from rheumatoid arthritis. Is ProArgi 9 Plus effective against RA. Thanks



HTM Admin October 21, 2013 at 7:49 pm


Thanks for your question. PA9 is not specifically formulated toward RA but there are some that have success using the V3 system which includes PA9 as one of the products. See more here


Angela October 3, 2013 at 3:13 am

I started PAG9 plus and got really diarrhea . Also my entire left side of my abdomen from my ribs down is bubbling and very painful. When I take ARG9 it causes this area to burn rally bad. Now I have a constant pain in this whole area and I stopped ARG9. Please explian


HTM Admin October 8, 2013 at 10:19 pm


I’m sorry to hear about your experience. Have you spoken to your distributor? This could be a several different things, they can assist you through it. If you are not working directly with a distributor yet, please feel free to drop us a direct note via the contact page and we can assist you further.


Karen April 28, 2013 at 3:34 am

Hi I have heard and read a lot of things about pro-argi9 all of which are very positive in its effects to people’s health. So I thought I would give it a try, I have only taken 1 scoop per day over a 3 day period – I thought I would build it up slowly to 2 or 3 per day over a few weeks. Reason being I have M.S. and I didn’t want to shock my body by introducing something new at to fast a rate. This morning I googled M.S. & pro argi use, a credible site came up and it’s recommending that M.S. sufferers should not take anything that increases nitric oxide, which I understand pro-argi9 does.
Here is one of its excerpts,
Herbs can be helpful in treating many disorders, but herbs high in L-arginine may increase nitric oxide and MS damage. Chinese foxglove roots, or Rehmannia glutinosa, and black cumin seeds, or Nigella sativa, contain L-arginine and stimulate the production of nitric oxide, according to Dr. James Duke. A report in the 2003 issue of “Alternative Medicine Review” notes that the leaves of aloe vera are also rich in L-arginine. While these herbs may have significant health benefits for many people, you should not use them if you have MS.
Anyway after reading this I’m feeling reluctant to carry on its use, do you have any information which could clarify my now indecision as whether to carry on taking pro argi9. I would ask one of the medical staff who deal with people who have M.S. but they are not really interested in what they would call “alternative treatments” basically they have no knowledge in this product & if it would be useful or helpful in improving my health. I also have borderline high blood pressure & high cholesterol levels which I was also hoping this product would help with, but I feel I may be in a catch 22 situation, it would help with blood pressure & the cholesterol but worsen my M.S. and all the symptoms that come with that.


HTM Admin April 29, 2013 at 9:15 am


Thank you for your comments. You have valid concerns that I share as I have a sister-in-law with MS. 1st of all who is your distributor? I did not find you in our database. 2nd if you have a doctor that will not comment on the connection between MS and NO, you need a new doctor. The pathology of MS is well documented and is by no definition an “alternative” substance. You body natually produces NO and Proargi-9+ is designed to support and improve that natural function. The report you noted is a bit old and additional studies are available. I found these reports.

Nitric oxide (NO) molecules have one of the most important roles in the pathogenesis of multiple sclerosis (MS). It has been stated that a continuous and high concentration of NO metabolites in CSF and in the serum of MS patients in relapse may cause toxic damage to myelin and oligodendroglia

Circumstantial evidence suggests that NO has a role in several features of the disease, including disruption of the blood-brain barrier, oligodendrocyte injury and demyelination, axonal degeneration, and that it contributes to the loss of function by impairment of axonal conduction. However, despite these considerations, the net effect of NO production in MS is not necessarily deleterious because it also has several beneficial immunomodulatory effects.

In conclusion, MS is a serious condition that you must have a doctor as a partner to work through. If you are not happy with your doctor find one you can work with. As I am not a doctor and cannot advise you on how to take any substance specifically I must leave you with information for you to decide for yourself.


Michelle April 7, 2013 at 9:54 pm

Hi, I just started taking proargi 9 plus 3 days ago. I took it in the morning and felt sick all day(1 scoop) then around 5 pm I felt like I was going to throw up and was dizzy and felt hot. I have been diagnosed with Rhumatoid Arthritis, but have alot of pain in my legs(mainly lower legs) which has not been diagnosed as of yet. Day 2 . I took another scoop and off and on all day I felt aweful cramping in my stomach, felt like vomiting and chills. Today I took half a scoop this time after breakfast and still felt terrible but, not as bad as yesterday though. I have had sensitivity issues with vitamin b could this be a problem and should I stop taking it or is this a normal cleansing response? I am scared that I have an allergy to the B vitamines in proargi but, do not know for sure. Any suggestions? I am so tired of being in pain please help


HTM Admin April 10, 2013 at 6:33 pm


Thanks for reaching out to us. First off you are more likely to see this from the sweetener in the Citrus Berry, not the Vitamin B. What flavor are your taking? Vitamin B is a foundational vitamin for energy in the body. You cannot survive without it. However, I am not a doctor and if you think you have something like this , PLEASE see your doctor.

ProArgi-9+ and Mystica have been successfully used in combating the effects of arthritis, so you should see some improvement. However your side effects are not normal.
If you would like to try a different flavor, please let customer service know and they would be happy to refund your purchase toward another flavor.


Debbie April 3, 2013 at 6:40 am

I just started taking Proargi 9+ five days ago…one packet in the morning, and Ihave experienced severe bloating and cramping. I do suffer from IBS but I am hoping this will pass so I can continue taking the product. Is this a normal side effect that will get better as I go?


HTM Admin April 10, 2013 at 6:25 pm


Which flavor are you taking? If it’s the citrus berry, you may be sensitive to the sweetener. Try the Mixed Berry or Grape flavors instead.


Grace March 31, 2013 at 8:54 am


Can proarg-9+ and mistify damage your teeth?
Have Graves and have been using this Products for 6 months now. In the beginning I felt less tired and slept well. After a month I was so tired, and I still am. do you know why this is so?


HTM Admin April 10, 2013 at 6:21 pm


Not that I’m aware of. In fact ProArgi9+ has xylitol in it which has been shown to improve and support oral health.


Cc March 30, 2013 at 7:33 am

I have systemic lupus and very bad neuropathy in my feet. I started proagri9 and the three times I have taken it — only once per day because I’m hypersensitive to so many things — i felt each time that my body temperature was 200 degrees, sweating for 8 hours continual. Very uncomfortable. Is this something that can be explained? Thank you for your time.


HTM Admin April 10, 2013 at 6:17 pm


This could be caused by the vasal relaxation that can occur when taking ProAri-9+. Think of it as unkinking the hose in your blood vessels. It can feel very warm. This is not common for most users but with someone who has severe neuropathy this could occur. It is actually a sign of improved blood flow. If it persists, please discontinue use and as always check with your doctor.


Carol March 8, 2013 at 12:15 pm

Is Proargi 9+ a blood thinner? I will have eye surgery in a month. Should I stop taking Proargi prior to and after surgery for a while?


HTM Admin March 11, 2013 at 8:44 am


ProArgi-9+ has no interactions on platlets or thinning of the blood. It is directly associated with stimulating the body to produce nitric oxide. Nitric oxide is a trigger molecule for the bodies natural healing processes. REsearch behind nitric oxide as a trigger molecule was awarded the Nobel Prize in Medicine in 1998.


ALMA February 18, 2013 at 3:25 pm

Tomo Pro argi 9 y……… a ayudado en el cansancio de mis piernas, dolores de mis piernas, y yo solamente tomo una cucharadita cafetera y media más al día, si la recomiendo, cada ser humano respondemos diferente a la toma, y yó me siento bién muy bién con poca dosis.
saludos desde México


HTM Admin February 18, 2013 at 3:28 pm

For the non Spansih speakers here’s a rough translation:
Tomo ……….. Pro ​​argi 9 and helped me with my legs fatigue, pain in my legs, and I only took one and a half teaspoon coffee a day, if I recommend it, each being respond differently to human decision, and I feel good very well in low doses.
Greetings from Mexico


Mazza February 16, 2013 at 8:36 am

Thanks for the feedback about the coffee intake. I’m trying to find reference or studies to support the claim that your product increases sperm count by 250% in 2 weeks. Do you have anything at all? In fact your website is devoid of credible evidence on most of your claims which is a pity. I can see testimonials etc from well meaning medical practitioners but there is little science-based evidence and once you scratch the surface, they are flimsy at best. Many of the people coming to you, including myself, are searching out your product to overcome sometime serious problems in their lives and they need to arm themselves with facts to discuss with their physician to make informed choices. I tried L Arginine a few years ago and I noticed some small differences here and there and felt good about taking it. There was, and still is, no credible recommendations on dosage levels apart from “the more you take, the better” and I stopped taking it after a while without any noticeable change to my wellbeing. (I understand the affects may be internal in nature and subtle) If you make the impression your product is based on science then you should do the responsible thing and be scientific with your claims and recommendations.


HTM Admin February 18, 2013 at 6:23 pm


I am not aware of any official claim of the product doing this. While I can appreciate your need for evidence, our site is not intended to be the definitive source for all scientific information. I do however hear your suggestion (however indirect) for more research information. We will take your suggestion and add more clinical data associated with legitimate claims and not heresay. In the meantime feel free to view some data on one of our companion sites here.

As for dosage, we have clearly outlined the manufactures suggested dosage and regimens on our site here and here.

2 scoops daily for sustained usage, or up to four were used in the HDHI Human Clinical study mentioned on our site here.

We also have several general l-arginine research articles on our site here.


Mazza February 15, 2013 at 5:56 pm

If I drink coffee in the morning and take ProArgi-9 around the same time, will the coffee affect the efficacy of ProArgi-9? (Espresso + milk)

Do you have access to studies or evidence of ProArgi-9 increasing sperm count or used as a part of IUI or IVF programs?


admin February 15, 2013 at 11:37 pm


I’m not aware of any contraindication with these however, I can say that one recommended regimen for HGH production stimulation calls for an empty stomach immediately before bed.


george skinner February 14, 2013 at 5:44 am

I’ve been taking Proargi 9 plus for almost 1 year and think it’s great, I’m from the uk and now cannot get proargi 9 plus mixed berry only the citrus brand, can you tell me why the agents for synergi can not get the mixed berry or can you direct me to someone who can supply to the uk mixed berry,


admin February 15, 2013 at 11:27 pm


I’ll look into it and see if I can get you some answers. Not sure at this point.


steve sarnicola February 5, 2013 at 6:02 pm

I am 56 year old man in good shape. I have a mitral valve prolapse from birth. does your product have a benificial effect? thank you


admin February 15, 2013 at 11:34 pm


I’m not aware of any direct effects on prolapses. My daughter also has a congenital issue with her tricuspid valve. My personal research as well as discussions with various cardiologist over the years has yielded little endorsement of NO (nitric oxide) doing anything directly for the specific condition. I did however learn recently that NO is commonly given directly after many heart related surgeries. AS you may know, ProArgi-9+ is SPECIFICALLY designed to stimulate the body’s production of NO. That’s its degign.


Joey January 19, 2013 at 12:57 pm

Is proargi 9+ FDA certified? Also what is the NSF certification? Thank you. Joey


admin February 2, 2013 at 1:36 pm


This is an excellent questioon. Most all OTC nutritional supplements are not FDA certified hence the required disclaimer on the product pages. This leaves it up to you as a consumer to determine if a manufactures uses quality ingredients and processes. This is where NSF Cerification comes in. They are an independent not-for-profit organization that establishes high standards in manufacturing. Synergy Worldwide products are NSF certified safe, responsible and high quality. You can read more about the NSF here.

You can also read more about the Synergy Worldwide’s Product Quality Assurance here and here. Simply put. Synergy Worldwide products are among if not THE best in the world for quality and manufacturing. And they are willing to prove it. Check out the link for more.


gemmamatthews-rogers January 10, 2013 at 4:55 pm

My husband suffers from angina and has high cholosterol .He had stopped taking the dr’s medication to lower his cholosterol and used five containers of proargi9 plus after which he had a blood test and his cholosterol is still elevated. Should he have continued with the dr’s medication whilst taking the proargi?


admin February 2, 2013 at 1:24 pm


You say your husband took 5 canisters. How much was that per day? The study mentioned on our site had measurable improvements with 4 scoops daily.


Lilian Thomas January 10, 2013 at 6:48 am

Hi my friend has been trying to get me to try ProArgi-9+ for months now, I’m kinda reluctant to try it due to my policystic kidney decease ( I can’t take no anti inflamatory ), I was just wondering if any of ProArgi-9-+ can effect my cystic kidney?


admin February 2, 2013 at 1:22 pm


Thank you for you question. I honestly do not know the answer as I am not a doctor nor am I familiar with your particular condition. You may want to check with your doctor and ask him abou the product. You can print off the label of ingredients from our site and take it into your doctor for review. Please keep us posted and we will update the community here.


Mary January 3, 2013 at 10:52 pm

I have a past history of shingles and still have some post-herpetic pain. What dosage do you recommend, since I have read that large amounts of argenine may aggravate previous shingle sites?


admin January 8, 2013 at 8:14 pm

I would recommend the dosage of 4 scoops daily used in the study spoken of here from the High Desert Heart Institute.


admin January 8, 2013 at 8:14 pm

I would recommend the dosage of 4 scoops daily used in the study spoken of here from the High Desert Heart Institute.


Bhagwan Korotana December 13, 2012 at 7:20 pm

I have a bypass surgery. i am on blood thinner. i can take proargi 9 plus while taking blood thinner. I have blood bp 150/86


Penny November 29, 2012 at 5:19 pm

My fasting sugar is high and my triglycerides are also on the high side. Also I was told that I have fatty liver. Can Proargi9+ help and what dosage should I take to bring these levels down. Thank you,

Also my cousin is slowly recovering from a mild stroke and is also on thyroxin. Can he take proargi9 to assist in his recovery? Thank you for your quick response


Penny November 24, 2012 at 4:42 am

Hi Jim, my fasting sugar is high and my triglycerides are also on the high side. Also I was told that I have fatty liver. Can Proargi9+ help and what dosage should I take to bring these levels down. Thank you, Penny


admin December 19, 2012 at 9:55 am


While Proargi-9+ can help improve health, it’s mechanisisms are not directly targeted at blood sugars and lipids.


CAROL November 7, 2012 at 9:25 am



Jim Brogan October 18, 2012 at 4:28 am

I’m a newcomer to proargi-9+ I hear that 5 grams is the dose… but dosage seems to depend very much on your own state of health… and I hear in testimonials persons taking
anything from 4 to 9 “scoops” I know what 5 grams equals… a bit more difficult when we
talk about scoops… I would like to see a general guidline (if possible) in grams… since it
seems dosage is going to vary quite a bit between individuals…. personally I am 70 years
of age and don’t take any medication… but would like to bring my BP and cholesterol levels down since both are above borderline high… but also importantly would want to to take a
high enough dose to make an impact on plaque in the arteries.
thankyou… Jim — Scotland


admin October 29, 2012 at 8:26 am

Hi Jim,

Scoops is how the Proargi-9+ is measured for dosage. There is 5g of elemental free form l-arginine in a 1 scoop (along with the other active ingredients). The recommended dosage on the side of the can is 2 scoops per day. I like to call this a maintenance dose. The study conducted by the High Dessert Heart Institute we note on our site used a dosage of 4 scoops per day. I have also heard of others taking more as tolerated. There is no know toxicity of l-arginine in the form we use but please cusolt your doctor or pharmacist to assist you with dosages that are larger than the manufacturers recommendations.


Eltruvel Alconcel September 10, 2012 at 2:24 am

I desperately need help! My mom is has been in kaiser hospital for a week now from having a heart attack 3 out of the 4 bypasses are now clogged and because she has a weak heart now, her kidneys are in bad shape so now her body is swollen and is producing enough eurine to flush out her system. Her current condition is very low blood pressure, the doctor don’t to do a daialisis because it may cause her her blood pressure to drop even more. She is also diabetic and take insulin shots twice a day. I don’t know what to do and I don’t want to loose my mom.
I have been on YouTube and found how proargi 9 has helped other people. I’m desperate and I want to do anything to prolong my moms life. Can this product help her?


Eltruvel Alconcel September 10, 2012 at 2:29 am

Sorry for the typ-O, I ment to say the her kidney id not producing enough eurine to flush out her system.


admin September 10, 2012 at 6:38 pm


First and foremost, I am sending you my best hopes for your mother. I’m sure others here will as well.

I cannot tell you that Proargi-9+ will be a life saver for your mother but I can offer you a 100% moneyback 120-day guarantee. Order some right away. I would recommend you consult with her doctors before giving her anything as they need to understand what she is getting. If it were me I would go strong and start with 1 scoop 4-6 times daily. Again please consult with your doctor as she is in there care and other protocols they may be doing may contradict the l-arginine.

Print out the ingredients and research you feel is related and take it with you for the doctor to examine. ProArgi-9+ is not just another supplement, it has real proven clinical results backed by Nobel Prize winning science. If your doctor is not open to simply looking at the science, then get one that will.

And please, let us know how things go. While I understand this is a very personal issue for you, we all here want to support you where we can. You and your mother will be in my personal prayers.

Owner – HTM


hannah February 16, 2015 at 6:59 pm

Hi why would you reccomend pro argi when this pt is hypotensive? Surely you run a high risk if dropping their bp further resulting in systemic failure


HTM Admin March 5, 2015 at 2:41 pm

It seems to me you answered your own question.

Ian April 12, 2012 at 6:56 am

Hi, I have been diagnosed with CCSVI, Chronic Cerebralspinal Venous Insufficiency, narrow veins in the neck, so there is poor blood flow out of the brain. Many people with Multiple Sclerosis (MS) have CCSVI. Has Proargi-9 proven to be a successful treatment for people with MS and/or CCSVI? It could be working by the nitric oxide causing a relaxation of the veins in the neck thus opening them up and helping blood flow. Any comment would be appreciated. Thanks, Ian Cameron


admin April 18, 2012 at 11:51 am


While I’ve not heard of ProArgi-9+ used specifically for CCSVI, I can tell you that you are exactly correct on what it directly does. ProArgi-9+ signally to the body to produce nitric oxide. Nitric oxide is a trigger molecule for many beneficial and repairative processes in the body. It’s discovery and benefits were awarded a Nobel Prize. You can find more about this in our doctors section.

One of these direct benefits is the relaxation of the of the vessel walls. This in turns allows better flow, lowers blockage risks, and improved blood pressure. Cholesterol does not stick to the vessel walls as much (lowers risk) which is the primary reason for high numbers being a risk. It is the sticky factor, not the volume specifically that is dangerous. Vascular surgeons know this but the drugs today only reduce the amount of cholesterol, not it’s sticky factors. This is why research shows the actual risk of a cholesterol related event while on drugs is only minimally improved. It still sticks.

I hope this helps you and I look forward to hear more about your results in a few months. Give it a try. It’s guaranteed for 120 days!


Ron April 10, 2012 at 1:03 am

I was having diarrhea in the mornings, immediately after my morning dose (I had mixed berry). The evening doses did not cause diarrhea. I quit taking my morning doses for about a week, and the diarrhea immediately stopped. I called and was told that the probable cause was the xylitol in the mixed berry, so I exchanged it for grape. I took one dose of the grape in the morning, and immediately had diarrhea again. I guess I’ll try smaller morning doses and see if I can develop a tolerance, and maybe a probiotic as well – as if this were not insanely expensive already.


Wendy April 4, 2012 at 1:06 pm

My husband has been taking proargi 9 for about a month he feels better but ever since starting this he has had diarrhea is there a way to decrease the diarrhea episodes?


admin April 4, 2012 at 1:15 pm


Some people are sensitive to the ingredients in Citrus-Berry. The Mixed-Berry and Grape are formulated a little differently and may provide your husband some relief. All the flavors contain the same active ingredient formulations (l-arginine, etc).

I have also seen where some people have success with smaller doses at first and ramping up to the desired dosage (as much as 4-6 scoops daily) as their body could tolerate. This is more than the manufactures daily dosage but on target with studies that have shown significant health improvements with ProArgi-9+.

I would also recommend a good probiotic to stabilize the digestive tract bacteria. I have seen this help others as well.


Tom Averett March 16, 2012 at 2:18 pm

I have celiac disease. Is Proargi9 gluten free?


admin March 17, 2012 at 4:46 pm


All ProArgi-9+ products are gluten free.


Bernice March 6, 2012 at 7:54 pm

My husband had bypass surgery 4 years ago (5 blockages) and has been on medication ever since. The ProArgi-9 Plus promotes cardiovascular health while at the same time cautions against using if one has coronary artery disease or had ever suffered a heart attack. This seems to be a contradiction and I was wondering if you could elaborate.

PS. My husband’s medication does not include blood thinners.


admin March 9, 2012 at 10:34 am


I am not qualified to give you the detailed answer you need. I will however forward your question to our experts panel who should be able to give us clarification. I will post their response here when I receive it.

Thanks for your interest.


Al Angell October 8, 2011 at 8:56 pm

I have been taking proargi9plus for about 2 weeks. Have there been any reports of micturination?


admin October 10, 2011 at 11:02 am


Thanks for your question. I have not heard of any reports of micturination. It is however seems possible that you body is releasing swelling and associated water reserves as your body adjusts to the relaxing vessels and improved blood flow. One of the known effects of ProArgi-9 Plus can be a reduction in general and specific inflammation. When inflamation caused by water retention and excessive fluids is reduced, an increased need to urinate my occur as those fluids are removed from the body.

As always, if uncomfortable symptoms persist discontinue use and consult your physician. I am not a doctor so I would run this one by yours.


Andrew September 6, 2011 at 7:38 pm

How long should you take proargi9 before taking a break as it relates to the following sentence:

“Long-term use of arginine supplements is not recommended, as it may result in thickening and coarsening of the skin and/or nitrogen imbalance in the body.”


admin September 7, 2011 at 10:39 am


That statement does not hold true for our formulation. Arginine supplements are not equal and as a result some use inferior ingredients and formulations. As a result they may have side effects not found in high quality formulations. The formulation sold here from Synergy Worldwide does not have the effects you noted.


Andrew August 12, 2011 at 4:37 pm

What if you do have adverse side effects like some chills or numbing sensations could you be taking to much even at 5 grams of L. Arginine? Would halving the dosage and taking it at two different times of the day work?


admin August 12, 2011 at 5:36 pm

I have not personally heard of any side effect such as these. As with anything reducing the dosage or eliminate the supplement is a good way to troubleshoot the possible causes. I have personally had odd chilling sensations from niacin flush etc, but not from l-arginine in any way.


John August 10, 2011 at 1:37 pm

I have been taking ProArgi-9 for about a week now and have noticed some slight chest discomfort. Seems as though I’m very aware of my heartbeat and something might be off. Has anyone else reported anything like this?


ron palmer July 26, 2011 at 2:13 pm

My husband has been taking pro argin9-plus for about 6 weeks and has gained 6 lb he has been on a diet as well should he stop taking it sheila


admin July 28, 2011 at 2:09 pm

Thank you for your comments. It is not common to have weight gain with l-arginine supplementation. In fact quite the opposite is the more common effect, weight loss. Although, I would not be concerned too much, you should check with your doctor when possible for other potential causes especially if he is on a diet already. One pound a week is quite moderate.


Mary Thiessen March 27, 2011 at 11:47 pm

My husband is taking ProArgi 9 Plus PR for a month, he has gained 7 lbs, mostly around the abdomen, and his breasts have grown considerably. His diet nor life style has had no changes in this time. He is very concerned, can you understand the mweight gain and the growth of his breasts.


admin March 31, 2011 at 11:09 am


I have not heard of this before. I personally take the product and as a diabetic have to keep an extra eye on my blood sugars due to the way ProArgi9 works.
Has you husband had any recent tests to test for blood sugar irregularities? The middle weight can be common in men but the sudden onset of weight could be a symptom of a larger issue. Although it is unlikely that the product is the cause, discontinuing the use of product and consulting with your doctor might be a good idea.
Please keep me posted on your findings. I would love to hear more.


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