L-arginine Supplements Comparison

There are many l-arginine products on the market made many different ways.  As an informed customer, we want you to have all the facts about the supplements you take.  Some products have fancy websites or ads but leave out critical information.  Others entice you with a low price or free shipping claiming to be the same as the best.

Don’t be fooled.

All L-Arginine products are not the same. The years or research and the science behind our formulation are CRITICAL to it’s effectiveness. When you get a cheap price you often get inferior elements. They don’t have to pay for the research and time of trusted experts and industry leading doctors and scientists.
Don’t let price be your only deciding factor. Trust a product with proven clinical results and years of successful use.  We hope the information below will aid you in your comparisons and decision.

Side by Side Comparison
Comparison based on information available as of August 2, 2010. All product names and trademarks remain the property of their respective companies.*The information, products and statments listed here have not been evaluated by the Food and Drug Administration. These product is not intended to diagnose, treat, cure or prevent any disease.
ProArgi-9 Plus TM
L-arginine Plus
Niteworks ®
L-Arginine YES YES YES
Elemental Pharmaceutical Grade YES NO NO
L-Citrulline YES YES YES
L-Taurine NO NO YES
D-Ribose YES NO NO
Grape Skin Extract YES NO NO
Resveratrol (Red Wine Extract) YES YES NO
Pomegranate Concentrate YES NO NO
Vitamin D YES YES NO
Vitamin B6 YES YES NO
Vitamin B12 YES YES YES
Vitamin E NO NO YES
Folate (Folic Acid) YES YES YES
Alpha Lipoic Acid NO NO YES
Trace Minerals YES YES NO
Produced in certified pharmacutical grade facilities YES UNDISCLOSED Unknown
Manufactured by a publicly traded company YES UNDISCLOSED YES
Formulated by Board Certified Endocrinologist YES UNDISCLOSED NO
Effectivness proven in human clinical trial YES NO NO
Price per can (single) $69 $39.95 $89.95
Price per can (3-pack) $54 $35.95 N/A
Price per can (4-pack) $50 N/A N/A
Price per can (6-pack/*jumbo can) $37.50* $31.95 N/A
Price per can (12-pack) $45 N/A N/A
Price per can (48-pack) $35 N/A N/A
Supplement Facts


The remarkable properties of l-arginine were validated by the 1998 Nobel Prize in Medicine, and since then have created a frenzy of interest in the pharmaceutical and nutraceutical fields. The efficacy of l-arginine as a therapeutic agent has been validated by thousands of scientific clinical studies. L-arginine is a vital amino acid that is best known for its cardiovascular benefits. In the body, l-arginine is converted to nitric oxide, which relaxes the arteries and regulates blood vessel tone and flexibility. This reduces stress on the heart, helps maintain already normal blood pressure levels and blood thickness, and improves circulation and overall cardiovascular function.*L-arginine is best known for its cardiovascular benefits. In the body, l-arginine is converted to nitric oxide, which relaxes the blood vessels. This reduces stress on the heart and improves circulation.
L-arginine is the body’s major source for nitric oxide synthesis. Without nitric oxide, human life would not be possible.L-arginine also reduces blood viscosity. Scientific studies have shown that l-arginine aids in reducing blood pressure levels. L-arginine also enhances health in aimmune function, stimulate the release of human growth hormone(HGH), and promote healthy sexual function. It may also boostenergy levels, help to build muscle,and reduce adipose tissue body fat.

Elemental Pharmaceutical Grade L-Arginine

Pharmaceutical grade is a term that sometimes refers to a material that meets the highest standards for purity and potency. There may not be an official “pharmaceutical grade” material category, but the phrase is intended to communicate that the material is properly authenticated and thoroughly tested for purity.  It’s appropriate for use in high quality products, including pharmaceuticals.  Our l-arginine is free form l-arginine, which replicates the actual l-arginine molecule created in the body. This is pure l-arginine, not a complex like l-arginine HCI which is an l-arginine salt.  In our formula 5 grams of l-arginine delivers 5 grams l-arginine.  Many competitors use lesser forms that are actually complexes and don’t deliver 100% l-arginine.


L-citrulline is an amino acid that is metabolized to yield more l-arginine, which in turn provides additional nitric oxide. L-citrulline helps optimize blood flow throughout the body and promote healthy energy levels.*
We can’t divulge the amount of l-citrulline in the formula because it’s part of our proprietary blend.  However, the amount was carefully selected to complement and enhance the efficacy of the l-arginine in the formula.  The two work together to provide long-lasting, efficacious benefits.   The results people are getting with our product are proof it is properly formulated with an effective ratio of l-citrulline to l-arginine.


D-Ribose is a naturally occurring sugar that has been extensively studied for its ability to enhance the recovery of energy compounds in heart cells.

Grape Skin Extract

Grape rinds or grape skins used to make wine contain the highest concentration of resveritrol.
Resveratrol or grape skin extract is a substance that helps the prevention of heart problems, skin problems, weight problems and certain illnesses such as cancer and diabetes. It helps a person lose weight because it processes the regular calorie intake of a person and makes the body feel like it is getting much less than what is being consumed. Scientists have tested these on mice and have discovered that no matter how much they feed them, they wouldn’t gain any weight at all. In fact, they appeared to be more energetic and active.

Resveratrol (Red Wine Extract)

This ingredient is high in antioxidants, anthocyanins, and polyphenols, which help protect the heart and reduce LDL oxidation.

Pomegranate Concentrate

Pomegranate contains superior antioxidants, known as punicalagins and ellagic acid. Pomegranate may inhibit LDL oxidation, support arterial wall strength, and enhance the activity of eNOS, the enzyme responsible for converting l-arginine to nitric oxide.*

Vitamin K2

Some products we’ve examined used inferior forms of vitamins such as vitamin K. It’s key that cardiovascular formulas use vitamin K2. In fact we use the form of vitamin K2 (menaquinone 7) that has been heavily studied for its ability to synthesize calcium in the bone and keep it out of the bloodstream. Lesser forms will not have the intended cardiovascular benefits.

Trace Minerals

Trace mineral complexes are not unique in most formulas. All foods will have some trace minerals. They’re ubiquitous in our environment. We have conducted testing on our formula and it too contains many trace minerals that we don’t even claim on the label. We don’t claim them because we don’t add them to the formula, they are just found naturally in many of the foods we eat, including some of the natural ingredients in ProArgi-9 Plus. The additional trace minerals found in some formulas is not that significant.

Publicly Traded Company with Pharmacutical Grade Facilities

Synergy Worldwide is a wholly owned subsidiary of Nature’s Sunshine Products, a 37-year-old, debt-free giant. Synergy benefits from this relationship with NSP in many ways. Nature’s Sunshine Products manufactures many Synergy products, and NSP scientists work with Synergy to oversee the design, manufacturing and production of all Synergy products. In 2002 NSP opened a new, state-of-the-art manufacturing plant, with mechanical systems and quality-control mechanisms comparable to those used in the pharmaceutical industry. No other natural-health company can claim this level of attention to detail and insistence on the highest levels of manufacturing excellence.

Also you have to be aware of the quality standards of the manufacturer. Many times manufacturers will produce products to lesser quality standards and give the impression that their facilities meet all current GMP requirements. Is the plant meeting current GMP requirements? How are their products tested for purity and potency? Do they have NSF Certification? NSF is the leading global authority reviewing and certifying high quality manufacturing facilities. Nature’s Sunshine Products/Synergy has NSF Certification, which is a critical validation of our quality standard

Formulated by Board Certified Endocrinologist

ProArgi-9 Plus was formulated in collaboration with leading l-arginine researchers such as Dr. J. Joseph Prendergast and other cardiovascular specialists who have conducted pioneering research in the proper application of l-arginine in promoting cardiovascular health. These experts have helped create the best l-arginine product on the market.


What’s unique about our formula is that we have the science, testing, and QA monitoring to produce the highest quality product. When you’re dealing with something as vital as your personal cardiovascular health you don’t want to skimp on ingredients or QA standards. You need to know that you’re getting the best product available manufactured and tested to the highest industry standards. Our formula will meet the label claim amounts for each ingredient, which is a major shortfall with many competitive products. We source the best materials and consequently we pay a premium for them. These are the main reasons our formula will be more expensive than other products. We don’t cut corners.

Effectivness Proven in Human Clinical Trial

A recently completed 90-day study at the  High Desert Heart Institute in California using ProArgi-9 Plus showed that this product is can truely live up to it’s nick name “The Miracle Molocule”.  Here’s just a few of the amazing results soon to be published in various medical literature and journals:

  • 18% increase in HDL Cholesterol
  • 40% decrease in triglycerides
  • 8% Glucose reduction
  • 25% decrease in c-reactive proteins
  • 11% reduction in creatine levels
  • 35% increase in magnesium levels (even though there is no magnesium in the product) magnesium is very important in improving heart health
  • Vitamin D levels increased by 183%
  • Systolic BP decreased by 13%
  • Diastolic BP decreased by 17%

Click here for more on the study results…

Required Disclaimer

*The information, products and statments listed here have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

{ 6 comments… read them below or add one }

Janet T November 21, 2012 at 6:28 pm

Dear Sir/Madam
I have just read about ProArgi-9 and am wondering about how it helps in Renal failure. Could you please explain. I would like to start on this product, But reading the article it only states on cardiovascular system.


Gerd laub, Dr.med. September 4, 2011 at 6:06 pm

where do i get the US formulation with 5g of l-arginine. In the web i can`t find it.

G. laub


Janet T November 21, 2012 at 6:31 pm

I read about toyr product and would like to know how it will help in Renal failure and how does it affect the kidneys


admin December 19, 2012 at 9:57 am


I cannot comment on renal failure effects as I am not aware of any direct or indirect effects that might help you. Please check with your doctor/pharmacist as well on the benefits of l-arginine on renal failure.


Gerd Laub, Dr.med. July 19, 2011 at 4:41 pm

i have one question: i am using Por Argi 9 plus, how much l-arginine is in one scoop. On the container is standing: per 3,25 g serving l-arginine 1,60g.
I take the product, although i`m healthy (i am 35 years old). I don`t have heart diseases, is one scoop a day enough?

G. Laub


admin July 25, 2011 at 10:54 am


Thank you for you question. The amount of elemental l-arginine can be different in depending on the country in compliance with local laws. In the US formulation, there is 5g (5000mg) of l-arginine. I have submitted an inquiry to our international support for Germany and will post back here any information I receive. It appears from what you have shared that there is 3.25g of l-arginine per serving (1 scoop). And since you are trying to maintain an already healthy condition I would say you are probably fine. Remember there are two ways to take ProArgi9-Plus that have different benefits: for heart health and for HGH boost (anti-aging). You can read more about the protocols here: How ProArgi-9 works


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