ProArgi-9 Plus – L-arginine Complex

ProArgi-9 Plus is Synergy’s top selling product and the cornerstone of any nutritional regimen. One serving contains 5,000 mg (5 grams) of elemental pharmaceutical grade l-arginine. Often referred to as the ‘miracle molecule’, l-arginine has potent health-enhancing properties. High Desert Heart Institute found very compelling positive results including the potential to reverse heart disease!  See the full results here. There are also many medical publications that have documented the benefits of l-arginine use.  Click here to read more.

L-arginine benefits the body in a myriad of ways. It stimulates the production of nitric oxide in the body….to promote anti-aging properties, sports performance, enhance sexual performance, and boost the immune system. We can’t ignore the power of arginine any longer!
– Dr. Joe Predergast

ProArgi-9 Plus was formulated in collaboration with leading l-arginine researchers such as Dr. Joe Joseph Prendergast and other cardiovascular specialists who have conducted pioneering research in the proper application of l-arginine in promoting cardiovascular health. These experts have helped create the best l-arginine product on the market.

L-arginine is best known for its cardiovascular benefits. In the body, l-arginine is converted to nitric oxide, which relaxes the blood vessels. This reduces stress on the heart and improves circulation. L-arginine is the body’s major source for nitric oxide synthesis. Without nitric oxide, human life would not be possible. L-arginine also reduces blood viscosity. Scientific studies have shown that l-arginine significantly reduces blood pressure levels.

L-arginine also enhances health in a number of other ways. It improves immune function, stimulates the release of human growth hormone (HGH), may boost energy levels, helps to build muscle, and reduces adipose tissue body fat.

ProArgi-9 Plus is a unique product with far-reaching health benefits and powerful support for the cardiovascular system. With ProArgi-9 Plus, you’re giving your body the support necessary for a long, healthy life.

ProArgi-9 Plus now comes in 3 flavors: Citrus Berry, Mixed Berry and Grape.  All have the same powerful active ingredients but have different forms of sweetening, like monk fruit or Xylitol (label information below).


  • Supports cardiovascular health
  • Enhances blood flow to vital organs
  • Combats the negative effects of premature cardiovascular aging
  • Sweetened with Xylitol to enhance oral health
  • May aid in decreasing body fat
  • Anti-aging benefits
  • Stimulates the natural production of HGH (human growth hormone)
  • Maintains healthy blood sugar levels already in normal range
  • May boost energy levels

These and other powerful benefits were documented in a recently completed at the High Desert Heart Institute.  Among them is evidence that shows the potential for a reversal of heart disease!

Listen to the recorded conference call sharing the studies’ preliminary results publicly for the first time.

Audio clip: Adobe Flash Player (version 9 or above) is required to play this audio clip. Download the latest version here. You also need to have JavaScript enabled in your browser.

Read the study summary
Read the full study results here…
ProArgi-9 Plus Live Blood Analysis
Read more clinical documentation and publications here…


Joe Joseph Prendergast, MD, is a distinguished certified physician whose advanced research and experience has contributed significantly to Synergy as well as to the medical and scientific fields as a whole. In addition to his role as a practicing physician for over 35 years, Dr. Joe is an accomplished scientist, researcher, and humanist. His research regarding l-arginine contributed to the development of Synergy’s signature product, ProArgi-9 Plus.

Since 1991, Dr. Joe has been personally using l-arginine and recommending it to his patients. He has become an expert on the many properties and benefits of this amino acid and he understands l-arginine’s essential role in maintaining vital heart health. “L-arginine benefits the body in a myriad of ways,” explains Dr. Joe. “It stimulates the production of nitric oxide in the body, which dilates the blood vessels and helps them relax and restore elasticity. L-arginine is also important in cell division, immunity, and the secretion of hormones. We have now learned more about how l-arginine uses the two natural pathways into the brain to promote anti-aging properties, sports performance, enhance sexual performance, and boost the immune system. We can’t ignore the power of arginine any longer!”

Dr. Joseph Prendergast
• 2008 – ADA “Father of the Year”
• 2005 – AMA Certificate of Recognition
• <1% admissions in 17 years!
• Prestigious Panel Member
• Staff Physician – Stanford

In part due to his use of l-arginine in his clinic, Dr. Joe has a remarkable record of less than 1% patient hospital admissions in 17 years including heart attack or stroke. He has received many awards including “Father of the Year” in 2008 from the American Diabetes Association and the Father’s Day Council of Silicon Valley and a Certificate of Recognition in 2005 from the American Medical Association for demonstrating outstanding commitment to eliminating health care disparities in the area of access.

Dr. Joe is board-certified in internal medicine as well as endocrinology and metabolism. He graduated from Wayne State University in Detroit, Michigan, completed a fellowship in endocrinology and metabolism at Henry Ford Hospital in Detroit, and fulfilled his research fellowship at the University of California, San Francisco. He has served on many prestigious local and national committees and review panels including the American Board of Internal Medicine, the State of California Legislative Task Force on Diabetes and Obesity, and the American Association of Clinical Endocrinologists. Among his many positions, Dr. Joe has served as an Associate Clinical Professor of the Department of Medicine at the University of California Medical Center and is currently a staff physician at Stanford.

Dr. Joe has published 50 medical articles in well-known publications such as the Journal of the American Medical Association and the New England Journal of Medicine and Diabetes Care. In 1986, Dr. Joe formed a single specialty endocrinology practice, Endocrine Metabolic Medical Center, and a non-profit research foundation, Pacific Medical Research Foundation. In 1999, he founded DiabetesWell, an eClinic that helps patients with diabetes lead healthier, longer lives.

From his office in Palo Alto, CA, Dr. Joe sees a variety of patients facing both shortened lifespan and restricted lifestyles. He is one of the foremost practitioners and proponents of l-arginine as a treatment of choice, and through his practice he helps his patients to modify their lifestyles and begin a new, more rewarding life with fewer restrictions and broader opportunities for improvement.



Mix 1 serving (1 scoop providing 5 g elemental L-arginine) with 4-8 oz. water (depending on individual taste).  Stir to dissolve.  If water is very cold, mixture will take about 1 minute to dissolve. One serving (1 scoop) may be taken twice per day.


There are two recommended regimens with differing focuses.  Both have positive effects on the overall body and heart health yet a slightly different in specific benefits.  Click here for more…


L-arginine is a vital amino acid that plays a role in a number of physiological functions in the body, but is best known for its cardiovascular benefits. In the body, l-arginine is converted to nitric oxide, which relaxes the blood vessels and regulates blood vessel tone and flexibility. This reduces stress on the heart, improves circulation, and lowers blood pressure.

The amino acid citrulline is metabolized to yield more l-arginine, which in turn provides additional nitric oxide. Citrulline helps to optimize blood flow throughout the body and promote healthy energy levels.

Folic Acid, Vitamins B6 and B12
These ingredients work together to naturally decrease homocysteine levels.

Red wine extract (Resveratrol)
This ingredient is high in antioxidants, anthocyanins, and polyphenols, which help protect the heart and reduce LDL oxidation.

Pomegranate contains superior antioxidants, known as punicalagins and ellagic acid. Pomegranate may inhibit LDL oxidation, support arterial wall strength, and enhance the activity of eNOS, the enzyme responsible for converting l-arginine to nitric oxide.

Vitamin K2
This vitamin keeps calcium in the bones and out of the arteries.

Vitamin D3
This vitamin has long been known to aid in calcium absorption, but new research shows that D3 also plays a role in healthy cardiovascular function and supports healthy inflammatory response.

Ribose Ribose is a naturally occurring sugar that has been extensively studied for its ability to enhance the recovery of energy compounds in heart cells.

This ingredient is a low glycemic sweetener that occurs naturally in the body. Unlike other sweeteners, xylitol has been shown to provide protection against tooth decay.
Supplemental Facts

L-Arginine Products Side-by-Side Comparison

There are a lot of supplements on the market. Not all are effective and some may even harm you. We’ve put together a comparison of 3 popular l-arginine products. Click here to see how they stack up…


Citrus Berry Mixed Berry Grape Active


{ 17 comments… read them below or add one }

HTM Admin April 10, 2013 at 5:43 pm


I’m not aware of anything in ProArgi-9+ that would help with sickle cell.


mairead Welby April 1, 2013 at 1:42 am

Hi i am wondering about sweetners in Pro argi 9 Citrus berry surlose ? I am feeling rather ill after taking this product? Mairead


HTM Admin April 10, 2013 at 6:23 pm


Some people have sensitivity the sucralose like you. The Mixed Berry and Grape flavors have alternative sweeteners in them. Give them a try.


Michelle March 5, 2013 at 2:18 pm

I have early Parkinsons what dose do you recommend?


HTM Admin March 7, 2013 at 3:39 pm


Parkinsons has more to do with dopamine levels than HGH. Although ProArgi-9+ may assist you some way, I’m not aware of it doing anything specific for this condition.


mark west November 25, 2012 at 12:52 pm

i have had 1 stent in my heart 2 years ago and am on 1 aspirin a day and 1 statin tab blood pressure ok could it benefit me . sorry i forgot to mention my age 52 , many thanks m west .


Carol Thatcher October 13, 2012 at 3:09 pm

We just started this one week ago so how long does it take to notice any changes?


admin October 29, 2012 at 8:31 am

Individual results times are varied from what I’ve heard directly from various experts including Dr. Prendergast. The conditions, dosage and bodies ability to tackle them vary so much that there is no set expectation. I would say though that if you are not seeing ANY results or change (even minor) on a 10+g/daily dosage (2 scoops) in 60-90 days then you likely need a larger dosage. Our product is guaranteed for 120 days for this reason. We want you to have results.


Timmy August 20, 2012 at 5:15 am

Can I use both products proargi-9 and core greens mix together?
And can I mix with juice for easy to swallow?


admin August 20, 2012 at 6:33 am


Thanks for you question. Yes you can mix with juice and take your core greens with it safely. I do that regularly. Although if you are looking for the HGH production benefits and are following that protocol (click here for details), it is recommended that you take ProArgi-9 alone on an empty stomach immediately before bed. For daytime regimens, taking with other items is fine. However with the flavorings of the ProAgri-9 being what they are you may find that adding it to a sweet juice may make it overly sweet. I personally like it by itself with water. Although I do not add but maybe 4oz of water. Any more makes it taste diluted to me. But, that’s my preference, not a requirement for effectiveness.


Sue February 24, 2012 at 5:37 pm



admin February 27, 2012 at 11:51 am


Thanks for you question. As with all conditions please work with your doctor, especially if you are on any medications. What I can tell you is we have had several customers who have had good results with Proargi-9+ and arthritis. I can tell you that it is my personal experience that when combating a particular condition that increasing dosage up to 4 scoops a day can have a better impact. This is the dosage that was used in the High Desert Heart Institute study featured on our site. Please keep us posted. We would love to hear how things go.


Paul Appleton December 6, 2011 at 11:29 am

I use about 4 oz of dilute ( 50% water) Welch’s 100% grape juice, dump in the single scoop, wait till dissolves, drops to bottom and mix vigorously. While doing so, I add another 2-4 oz water….the taste of the pomegranate is masked pretty well.


Barb October 12, 2011 at 4:29 pm

Is ProArgi-9 Plus available in a capsule? I think putting it in water has a horrible taste. Thanks.


admin October 12, 2011 at 9:00 pm


I’m sorry it is not currently in pill form. There are now 4 flavors to try, Citrus Berrry, Mixed Berry, Grape and Active (in the cart soon). The citrus berry is quite pleasant I think. The mixed berry flavor is not sweet enough for my liking. If you are not particularly concerned about a little more sweet in your drink , then give the Citrus Berry a try. I even mix it a little thick (less water) to intensify the flavor. If you made your purchase in the last 90-days you can easily do a return/exchange through customer service.


Wilva Leeds October 3, 2011 at 10:49 am

Is this something I must take forever or can it be discontinued when health has improved ?


admin October 7, 2011 at 10:21 am


Thanks for your question. As with an nutritional supplement you can discontinue use at your discretion. However, health is something to be maintained not simply to be done when there is an issue to combat. Good nutrition and exercise are always the best medicine. Supplement such as ProArgi-9 Plus are just that: supplements to your maintain your health. Supplements should never replace a healthy regimen but compliment it.


Leave a Comment

{ 4 trackbacks }